Circwlnr dichroism investigations of the secondary structure and influence of S-adenosylmethionine
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چکیده
The enzyme dans metbylase which recognizes and methylates the adenine in the palindromic sequewrce OATC in DNA was isolated and the secondary structure was determixzcd by CD spectroscopy and various predicting methods from the amino acid sequence. The interaction of &rn methylase with S-adenosylmew thionine was studied by CD spectr~scupy indicating a decrease of the: percentage of E-helix as the amount of Saderzcrsylmcthionine bound to the enzyme was increased.
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